GATAMBWA DENNIS MUKANDALA

Lecturer , College Of Natural And Applied Sciences

Education:

PhD in Biomolecular and Biomedical Sciences (Neuroscience Department) from University College Dublin (UCD)

Teaching:

I am currently involved in teaching the following courses:

• Vertebrate Anatomy and Physiology I & II
• Molecular Physiology
• Advanced Physiology
• Biochemistry
• Physiology and Biochemistry of Nutrition
• Neuroendocrinology and Behaviour
• Biological Methods and Techniques

Research:

Research interests:: I am very passionate in researching non-communicable diseases that affect the brain and spinal cord. There needs to be more research conducted in this area in Africa

Projects:

1. To investigate the Mental Health Challenges among Students and Staff at the University of Dar es Salaam: 2022 - 2023.
2. Parkinson’s disease and its Social and Economic Impact in Tanzania: 2018 – 2020.
3. Etiology of Poor Pregnancy Outcomes in HIV-1 positive Pregnant Women on Antiretroviral Therapy: 2018-2020.
4. To assess the Epidemiology and distribution of Hydrocephalus in Children at Muhimbili National Hospital in Dar Es Salaam Region: 2017 –2019.
5. A role for CREB but not COX-2 in the TNF-alpha-induced potentiation of LTP post hypoxia: 2017 – 2020.
6. Effect of CAG extended repeats on CUG-BP1 in cultured cells. August 2003 – May 2004.
7. Bit1 Mediates Apoptotic Function in a Phosphatase Dependent Manner: September – December 2007.    

Publications:

1. Kidima W, Mukandala G, Leonard O, and Nkungu D 2021 Placental Insulin-Like Growth Factor-1 Receptor, Protein Kinase B and Mammalian Target of Rapamycin are downregulated in HIV-1 positive women on antiretroviral drugs. Tanz. J. Sci. 47(5): 1675-1688.
2. Lanigan, S., Corcoran, A.E, Wall, A., Mukandala, G., and O’Connor, J.J. Acute hypotic exposure and prolyl-hydroxylse inhibition improve synaptic transmission recovery time from a subsequent hypoxic insult in rat hippocampus. Brain Res. 2018; 1701: 212-218.
3. Mukandala, G., Tynan, R., Lanigan, S., and O’Connor, J.J. The effects of hypoxia and inflammation on synaptic signaling in the CNS, Brain Sci. 2016; 6(6): 1-14.
4. Mukandala, G¹., Wall, A.M¹., Greig, N.H., and O’Connor, J.J. Tumor necrosis factor-α potentiates ling-term potentiation in the rat dentate gyrus after acute hypoxia. J Neurosci Res. 2015; 93(5): 815-829.
5. Gaultier, A¹., Wu, X., LeMoan, N., Takimoto, S., Mukandala, G., Akasoglou, K., Campana, W.M., and Gonias, S.L. Low-density llipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. Jour. Cell Sci. 2009; 122(8): 1155-1162.
6. Mantuano, E¹., Mukandala, G., Li, X., Campana, W.M., and Gonias, S.L. Molecular Dissection of the Human Alpha2-Macroglobulin Subunit Reveals Domains with Antagonistic Activities in Cell Signaling. Jour. Bio. Chem. 2008; 283(29): 19904-19911.
7. Krygier, E1., Lin, G., Mendes, J., Mukandala, G., Azar, D., and Jones, A. Segmental Dynamics of Head-to-Head Polypropylene and Polyisobutylene in their Blend and Pure Components. Macromolecules. 2005; 38(18): 7721-7729.